In the field of drug discovery, accurately predicting the interaction between drug entities can reduce the risk of patients in clinical treatment. Meanwhile, accurate prediction of compound entity relations can also improve the efficiency of drug development. Aiming at the shortcomings in the extraction model of chemical entity reaction relations, we apply graph convolutional neural network to the task of chemical reaction relation extraction, and propose a multi-view algorithm to extract compound reaction relation features. The algorithm considers not only the internal structure feature information of compound entities, but also takes into account the interactive graph information between entities. Thus, it can fully mine the structure feature information in the graph. Experimental results show that the proposed method has higher accuracy than the state-of-the-art methods.

Location-based social network (LBSN) is a new type of social network. Each user can not only establish friendships with other users, but also share their own events in different places by checking in. There is a large amount of auxiliary information in the location social networks, such as comment information, social information, geographic information, and so on. A large amount of auxiliary information has unique spatiotemporal characteristics, which can be used to alleviate the problems of cold start and data sparseness of the recommendation system. In this paper, we propose a joint convolution matrix factorization method that considers time relations, referred to as CMF-J. In a unified probabilistic matrix factorization recommendation framework, the method jointly considers the related comments of items, items relationships, users social influence and users comments. And integrates the processing results of the convolutional neural network to perform rating prediction. Finally, we conduct extensive experiments on the dataset Yelp. The experimental results demonstrate the superiority of CMF-J compared to several state-of-the-art methods in the two performance indicators of Root Mean Square Error and Mean Absolute Error.

BACKGROUND: The aim of this study was to conduct a bibliometric analysis of publications for neural tube defects (NTD) between 1980 and 2020.\nMETHODS: We identified and collected 3353 publications on NTD in the Web of Science database between 1980 and 2020. The keywords \"neural tube defects\" were used to obtain data.\nRESULTS: The majority of publications on NTD were original articles (55.47%). The leading country in terms of the number of NTD publications was the United States (USA) (35.82%) and the leading country in terms of productivity was Canada (67.5). The author who published the most NTD articles was Shaw GM of Stanford University. The Birth Defects Research Part A: Clinical and Molecular Teratology (5.07%) was the journal with the highest number of NTD publications. The most cited publication was the article by Czeizel et al. with 2244 citations. Among the keywords used in the literature, the most common one was \"neural tube defects\". Worldwide, the 10 countries with the strongest ties in terms of NTD broadcasting were the USA, United Kingdom, China, Canada, Ireland, the Netherlands, Italy, France, Germany and Hungary, respectively.\nCONCLUSIONS: The leading country in terms of NTD publications is the USA, the leading institution is University of London, the leading journal was Birth Defects Research Part A: Clinical and Molecular Teratology, the leading author is Shaw GM, and the leading article is ‘Prevention of the First Occurrence of Neural-Tube Defects by Periconceptional Vitamin Supplementation’.

Background: This meta-analysis was performed to evaluate the relationship between association of multidrug resistance gene 1 (MDR1) gene polymorphisms and idiopathic nephrotic syndrome (INS) susceptibility. \nMethods: Association investigations were identified and included from the PubMed, Cochrane Library and Embase databases on May 1, 2020, and eligible investigations were analyzed by meta-analysis. Odds ratios (OR) were used to express the dichotomous data, and the 95% confidence intervals (CI) were also calculated. \nResults: In this meta-analysis, we did not find the association of MDR1 C1236T (rs1128503), C3435T (rs1045642), G2677T/A (rs2032582) gene polymorphisms with idiopathic nephrotic syndrome susceptibility. Furthermore, the association of MDR1 C1236T (rs1128503), C3435T (rs1045642), G2677T/A (rs2032582) gene polymorphisms with SRNS or SSNS susceptibility was also not found. Interestingly, the MDR1 C1236T (rs1128503) gene polymorphism was associated with the susceptibility of SSNS developing into SRNS. However, this association for C3435T (rs1045642) and G2677T/A (rs2032582) gene polymorphisms was not found. \nConclusion: MDR1 C1236T (rs1128503) gene polymorphism was associated with the susceptibility of steroid-sensitive nephrotic syndrome developing into steroid-resistant nephrotic syndrome.

Frantz Fanon was inter alia, a political philosopher from Martinique. He was considered by some to be a political radical and an avid Pan-Africanist and Marxist humanist. He immersed himself in colonization per se, and especially in its often dire consequences for peoples in the human, social, and cultural spheres. He was a significant persona because of the intelligence of his reproaches of colonialism based on original and often deep philosophical thinking. In a work entitled Black Skin, White Masks, Fanon psychoanalyzed burdened Black people who were regarded by many colonizers as lesser beings in a world subjugated by Whites from predominantly European colonizing powers. He stressed the notion of Black Consciousness and how orthodox African nationalism was failing Africans in their quest for liberation. He made a point of learning how Blacks circumnavigated the White world through their acts of White-ness in an effort to retain a sense of worth. In another of his literary works, The Wretched of the Earth (1961) mistranslated from Les Damnés de la Terre, he elucidated on the notion that violence and the armed struggle through liberation movements, indeed had a key role to play in liberating peoples from colonization and oppression, and argued that antiblack racism was anathema. For such ideas, he has often been maligned as a philosopher. Some considered him to be unethical, on the argument that he was a proponent of violence. Such thinking negates the legitimacy of political violence at times in history. This brief study seeks to rectify the idea that he was a misguided and violent man rather than a conscious and sensitive human being, rightly seeking justice, egalitarianism and true liberation for colonized peoples.

This paper presents a nonlinear vibration of a Timoshenko beam having uniform cross section with isotropic material properties. Both ends of the beams have guided end conditions. Shape function, nonlinear stiffness matrix, mass matrix and the governing equation of motion is derived for the guided beam. The equations have been solved for predicting the free and forced vibrational behavior of the beam. Natural frequency of the beam was calculated as an output for the free vibration phenomenon and displacement as an output for the forced vibration. Numerical analysis and physical experiments were also performed for the validation of the analytical solution. A comparison among analytical, numerical and experimental results showed the proposed governing equation predicting system’s nonlinear vibrational behavior appreciably.

Protective effects of herbal feed additives Glycyrrhiza glabra and Tinospora cordifolia against the growth inhibitory effect of ochratoxin A (OTA) and associated immunosuppression and biochemical or pathomorphological changes were seen. The intensity of pathological and biochemical changes, the changes in relative organs\' weight and body weight, and the decrease of antibody titer were strongest in the OTA-treated chicks without antidote-supplementation, but the same were less pronounced in the chicks treated additionally with Glycyrrhiza glabra or Tinospora cordifolia. The higher relative weight of lymphoid organs of the chicks supplemented with both herbs revealed their beneficial effects on the immune system. The hepatoprotective effect of both herbs was evident, being stronger in the chicks additionally supplemented with Glycyrrhiza glabra as it can be seen from the pathomorphological findings and from the lower levels of ASAT and ALAT. A protective effect of Tinospora cordifolia on the bone marrow and kidneys was found, whereas Glycyrrhiza glabra was seen to increase additionally the serum levels of uric acid. It seems, that both herbs could be used as a practical approach to ensure a better utilization of OTA-contaminated feed as it can be seen from the better feed performance and the higher body weight in the chicks treated with the both herbs.

Purpose: Clinical impact of myocardial perfusion defect (MPD) as a diagnostic clue for acute myocardial infarction (AMI) may be limited by a relatively high rate of false negative or false positive diagnoses due to motion or beam hardening artifact on non-gated enhanced CT. The purpose of this study was to evaluate whether identification of coronary artery occlusion (CAO) on non-gated enhanced chest CT has additional value over MPD in patients with AMI.\nMethods: We retrospectively assessed 99 patients with AMI (group 1, n=33) and without AMI (group 2, n=66) who underwent non-gated chest CT. We analyzed the presence of MPD and CAO on non-gated chest CT. MPD on the CT was categorized using a five-point scale (0=no defect; 1= probably artifact; 2= possible MPD; 3=probable MPD, 4=definite MPD). \nResults: There were 42.4% (14/33) and 12.1% (8/66) patients with probable MPD (p=0.002), and 18.2% (6/33) and 0% (0/66) patients with CAO (p=0.001) in groups 1 and 2, respectively. The addition of CAO on non-ECG gated chest CT resulted in a slight increase in sensitivity (48.5%) for diagnosis of AMI compared with MPD alone (42.4%) without decreasing specificity. Simultaneous presence of CAO and probable MPD showed a low sensitivity (12.1%, 4/33), but 100% specificity (66/66) for the diagnosis of AMI.\nConclusion: Simultaneous presence of CAO and MPD on non-gated enhanced chest CT may be a suspicious clue for the diagnosis of AMI, although it is a rare occasion.

An analysis of the stability of sloping and circular three-layer shell structures with light transversal-isotropic filler, supported by rigidity ribs in the longitudinal and transverse directions is considered in paper. The quantitative dependences of the parameters of the stability loss on the physical and mechanical properties of the materials and the dimensions of these three-layer supported shells were obtained. The critical loads of freely supported three-layer shells with lightweight filler of four types which supported by one and three ribs in the longitudinal and transverse directions are given. The expediency of introducing rigidity ribs in three-layer shells is substantiated.