Backgroud. About 50 percent woman had psychiatry symptom before pregnant. They had consumed drug for the rest life. The drug was valproic acid. Consumtion this drug during pregnancy would made neurodevelopmental disorder like Autism Spectrum Disorder (ASD). Brain Derived Neurothropic Factor (BDNF) have a role in development of Nervous system dams. The serum level increase during pregnancy and exercise Valproid acid which is consumed in pregnant may cause the decrease of BDNF level. Aims. Our study aims to investigate serum level of pregnant mice exposed to valproic acid and to investigate relationship level of BDNF with two condition exercise or not in short time. It is important to study to know, if BDNF level of mother is the better marker risk factor born child with ASD. Method. Pregnant mice differed into 4 group (control/1, control with exercise/ 2, valproid acid / 3, valproid acid with exercise /4). Valproic acid 500 mg/weight single dose was given at 16 days pregnant continue exercise for 4 days. Serum BDNF mother was examined. Result. Statistically, All groups had no significant value (p>0,05). But mean of both valproid acid groups, relatively decreased than control group. Exercise did not change the level.Conclusion. It could be concluded that consumtion of valproic acid could changed physiology of secretion of BDNF during prenatal, this is may be the causa of neurodevelopmental Disorder.

A guelta is a small body of water that accumulates in the wadis, or drainage channels of the Sahara or desert after rainfall. These gueltas are used mainly by wild animals for drinking and plants that grow near them. Identifying these gueltas in areas with short water supply is of most importance. Identifying them on the ground requires enormous resources, experience and knowledge. Geographic Information System (GIS) is an incredibly powerful tool for analyzing an area and it is used in many ways, such as mapping the size of a Guelta or predicting where water will flow during devastating storm events. In this paper we review published work that combined Guelta determination with GIS or remote sensing technology. The aim is to establish a comprehensive reference where researchers can start from. Relevant research is scarce and basic. There is plenty to be learnt from research on surface water detection (wetlands) and applied to Guelta research.

Caudal regression syndrome is a congenital neural tube defect with a low incidence as it interferes with the development of the caudal part of the spinal cord. The exact mechanism is still unknown but various factors are responsible for it, worth mentioning is maternal diabetes and genetic factors. Early diagnosis depends on antenatal ultrasound with confirmatory radiological studies later on. Treatment depends on severity which involves a multidisciplinary approach with supportive treatment. In this case report, we present a case of a 5-year-old girl who presented to us with urinary and bowel incontinence associated with renal agenesis.

To compare the preliminary phytochemical and anticancer activity on Allium cepa L. (onion) and Allium sativum L. (garlic) was attempt in the present study. Onion and garlic scales are wasted has tons and tons but the scales as more medicinal value. The phytochemical studies were carried by using standard methods for the both species of Allium. Water and ethanol extract was obtained by maceration method and subjected to qualitative phytochemical analysis such as flavonoids, carbohydrates, steroids, terpenoids and alkaloids. Ethanol extract of both species of Allium shows the highest content of the secondary metabolites compared to water extract. They show the presence of carbohydrates, glycoside and alkaloids in the ethanol extract. However, the presence of flavonoids was reported only in the scales of onion. The present study shows the scale of both species of Allium possess various secondary metabolites The anticancer activity of A. cepa and A. sativum scales against breast and lung cancer cell line IC50 value was determined on breast and lung cancer cell lines (A-549 & MCF-7) for both Allium sps showed dose dependent inhibition of cells. A.cepa shows highest anticancer activity compare to A.sativum in lung cancer (IC50-33±0.3 at 35 µg/ml) . A. sativum shows highest anticancer activity compare to A.cepa in breast cancer (IC50 -29 ±0.7 at 25 µg/ml) .

Lots of people infrequently have the urge to change or improve their hair color, but are\nunwilling to use the harsh and, in some cases, potentially damaging hair dying chemicals found in\nmost marketable dyes and color rinses. In comparison to natural hair dyes are described to cause\nskin and other skin associated diseases. The manufacturing process is hazardous to health of the\npeople involved in the process and its application and also causes potential side effects to the\nconsumers of the products. Hair dyes derived from plants are safe to use. The method for coloring\nhair by applying an effective amount of herbal hair dye composition with distilled water as an\nacceptable carrier. The herbal hair dye shows permanent dying to the applied regions of human\nhair without producing any hair damage or hair loss or skin irritation when compared to the\nsynthetic and semisynthetic dyes. A few of the commonly used natural herbals are henna,\nchamomile, madder, beets, turmeric, walnuts¸ etc. In present study, tannin producing plants such\nas Henna (Lawsonia inermis), Brinjal (Solanum melongena), Pomegranate (Punica granatum),\nRidge guard (Luffa acutangular Roxb) and Raw Banana (Musa acuminata) were selected for the\nproduction of natural herbal hair dye.

In the present study, leaf variation of Betula medwediewii Regel. in Turkey was investigated with respect to its distribution pattern. This plant taxon is an euxine element and a distinct relict species in Turkey. The main aim of this study was to analyze the morphological leaf characteristics of four populations of Betula medwediewii growing at different elevations in villages of Turkey. Four populations of Betula medwediewii (Artvin-Arhavi, Artvin-Bor�ka (Camili), Artvin-Murgul, and Rize-�aml?hem?in) distributed in Turkey were selected based on their natural distribution. From the selected populations, 1200 leaf samples belonging to 40 individuals were measured by ImageJ (Image Analysis Software) in terms of seven leaf characteristics (petiole length, leaf width, leaf length, lamina length, leaf area, leaf vein angle, and number of leaf veins). According to the results of the hierarchical cluster analysis, Artvin-Murgul, Rize-�aml?hem?in, and Artvin-Bor�ka (Camili) populations form one group, on the other hand Artvin-Arhavi form second group in terms of all leaf characteristics. In addition, using correlation analysis, statistically significant relationships were determined among the morphological leaf characteristics. It is the important that preserving the Betula miedwiediewii, which was a distinct relict species in Turkey, because this taxon is a source of biodiversity and it can be maintaince the ecological stability of Turkish forest area.

Cotton is the world’s richest source of natural fiber. Meanwhile cotton plant is top ranked stress sensitive plant thereby effecting its yield and fiber quality. But, in climate change scenario, fiber yield and quality are being affected due to environmental stresses, especially heat, drought and salinity. Present study is aimed to identify cotton genotype harboring prominently expressed stress responsive genes. Four cotton genotypes (IUB-13, IUB-222, CIM-509 and MM-58) were evaluated under drought and salinity stress and expression of different stress responsive genes were evaluated. Pronounced expression of GhWRKY3, GhDREB2, GhMYB25 GhZFP1 and GhRDR6 was observed in cotton variety IUB-13 in stress condition (drought and salinity) as compared to control followed by IUB-222 which revealed that these genotypes possess substantial potential to cope with environmental hazards encountered in growing season and their utilization in cotton breeding program can prove be very much fruitful for developing cotton genotypes adoptable to climate change.

Simulation with standardized patients training can affect students\' cognitive, psychomotor and affective learning domains, inhaler drugs knowledge and skill gain qualification. This study used the Solomon four-group full experimental design.Both the pretest and training were effective on the posttest inhaler scores (F(1;116)= 8.12; p= 0.005). The mean score of the intervention group without pretest (36.70±7.51) was found to be higher compared to the control group (20.00±9.52) (t=7.55; p<0.001). The mean score of the intervention group with pretest was higher (36.90±10.06) than the control group (30.53±12.09) (t=2.22; p=0.031). The mean score of the control with pretest was higher than the control group without pretest (t=3.75; p<0.001). Intervention groups’ pretest scores were indifferent (t=0.87; p=0.931). Simulation training with standardized patients was effective in teaching how to use inhaler drugs.

Pathogenesis-related protein inhibitors of trypsin (PR-6 proteins) are one of 16 factors of immunity in angiosperms. Their activity in the aboveground parts of plants ensures preservation of nonspecific systemic resistance to unfavorable biotic or abiotic environmental factors. Trypsin inhibitor activity (TIA) has hardly been studied in leaves of wild representatives of Fabaceae Lindl. For the first time, studies of background values of TIA in the leaves of intact mature generative individuals of Hedysarum gmelinii Ledeb. in the mountains of Altai and Krasnoyarsk Territories, the Republics of Altai and Khakassia, in the range of absolute elevations of 300-2200 m were carried out. In most of the cenopopulations, high TIA values were detected (more than 25 mg/g of dry weight of ground leaves). Higher TIA were found in representatives of the species inhabiting more extreme northern part of the studied area and in the arid highlands of Southeast Altai. TIA in H. gmelinii leaves can increase during the years of unusual weather patterns (with sharp fluctuations in the environmental temperatures).