Because of this contemporary pandemic of Coronavirus-19 and several essays to cure or prevent this illness by chemical products or body self-immunity. Several drugs and medications were described to halt or decrease the impact of this Virus, this review is a study on the best protocols to helps health community. No therapeutics have yet been proven effective for the treatment of severe illness caused by SARS-CoV-2. Viruses are not affected with antibiotics but they help to prevent an opportunist microorganism like bacteria and protozoa. Other antiviral drugs are not efficacy against this virus because of the way and the resistance in fresh air. Results: The best-known medication is Chloroquine/Hydroxychloroquine which is an antimalarial or anti plasmodium drug used to control the intracellular charge of the protozoan Plasmodium sp. Another protocol proposed here is, the using of an antiviral drug using generally proteases inhibitor as Lopinavir/Ritonavir or Darunavir with Remdesivir that increase the charge of any other antiviral drug by the inhibition of the Cytochrome P450 enzymes. A good antibiotic to prevent the accompanied illnesses by other microorganisms is also suitable (Rifabutin). Conclusion: So, the treatment of SARS-CoV-2 consists of (morning and evening: chloroquine + Rifabutin) and Prezcobix and Remdesivir in the mid-day for 6 days. Note that this study needs to be confirmed with clinical experiments from health services in hospitals.

The time-dependent behaviour of three gypseous soils is investigated. The soils had gypsum content of 66%, 44% and 14.8%. The mineralogical and chemical properties of the soils were determined. Two series of tests were performed. In the first, collapsibility characteristics were investigated for a long period (60 days) by conducting single and double oedometer tests. In the second series, the effect of relative density on collapse with time was investigated. The samples were compacted to 40%, 50% and 60% relative density and then tested. The results of collapse tests showed that the relationship between the strain and logarithm of effective stress has two vertical lines. The first one represents the collapse settlement taking place within 24 hours, while the second one represents the long-term collapse. The collapse potential (C.P.) in both single and double oedometer tests increases when the gypsum content increases from 14.8% to 66% and when the initial void ratio increases.\n The results showed that the relations of collapse potential-logarithm of time relationship for soaked samples prepared at different relative densities under 800 kPa indicated that the C.P increases with time for the soil sample compacted at a relative density 60% and the increase is higher than those compacted at 40% and 50%. The curves start with a straight line then a curve concave downward with a high strain is observed. For samples compacted at 40% and 50% relative densities, the curves are interrupted by little soil collapses while the third curve exhibited smooth relation following the collapse.

Introduction: Considering the increasing number of breast cancer patients in Iran, as well as other developing countries, and due to its preventable, screening programs in an asymptomatic population and identifying individuals with suspected signs before the onset of the disease, is undeniable. If breast cancer is not detected and treated promptly, death will occur. But if the disease is diagnosed in early stages and treated timely, the chance of recovery will increase. The aim of this study was to investigate the status of women\'s performance in screening programs and determine the factors affecting it (breast self-examination, clinical breast examination and mammography) in women referred to Isfahan health centers.\nMethods: This descriptive-analytic cross-sectional study was conducted on 10,000 women aged 20-65 years old in Isfahan province with multistage cluster sampling. The total number of 9260 women responded completely to questionnaire and entered in the final analysis. The latent class regression analysis was used to evaluate the women\'s performance of breast cancer screening (breast self-examination, clinical breast examination and mammography) and factors affected this performance.\nResults: Overall, 63.5 % of women had Breast Self-Examination, 49.8 % had Clinical Breast Examination and 15.4 % had performed mammography. Based on the latent class analysis, 50.34 % of the women had poor performance and 49.66 % had good performance on screening methods. The most effective factor in the level of performance is related to history of breast disease (P<0.001). Breastfeeding (P<0.001), attitude toward this cancer (P<0.001), marital status (P<0.001) and awareness of different components of breast cancer (P=0.006) were among other variables affecting on the performance of women participating in this study. Increased number of children also had an inverse effect on the level of performance of women (P<0.001).\nConclusion: In this study, similar to other studies in Iran, in spite of the relatively high awareness, preventive behaviors have not been reported at optimal levels. The performance of women in breast self-examination was better than other screening methods. Approximately half of the women referred to the doctor and midwife for a clinical examination of the breast. The most important predictor of women\'s performance was the history of breast cancer. Educational programs are recommended through public media to encourage women to perform breast examination regularly.

The smoke of tobaccos is not just an unpleasant irritation but also a high public health concern, as chemicals enclosed in tobaccos remain a high risk to public health and environment. Substantial possible risk evaluation of N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) substances from sidestream smoke of tobaccos obtained from Canada, United States were inspected in this study. The particulate substance of sidestream smoke was collected from a Cambridge filter pad, further extracted using dichloromethane and analyzed with gas chromatography-mass spectroscopy (GC-MS). The NNN concentration was in between the range of 23.30 ng/cig - 115.20 ng/cig and NNK concentration were in between the range of 34.7 ng/cig - 153.4 ng/cig from sidestream smoke of tobacco. Mean of rising in lifetime risk values (ILCR) for NNN ranged from 0.94 ×〖10〗^(-5) to 4.17 ×〖10〗^(-5), and the NNK ranged from 22.18 ×〖10〗^(-5) to 92.05 ×〖10〗^(-5), respectively. The mean of margin of exposure (MOE) for NNN ranged from 6.71 ×〖10〗^3 to 29.67 ×〖10〗^3, and NNK ranged between 0.89 ×〖10〗^3 to 3.31 ×〖10〗^3, which represent possible concern. These resulted data propose that the exposure of NNN and NNK from sidestream smoke of tobacco required to be abridged for the sake of public well-being and for environment.

MicroRNAs (miRNA) are small non-coding RNA molecules of 21-25 nucleotides playing an important role in gene regulation of an organism. Regulatory role of miRNA in cellular and metabolic processes by binding to the target mRNA is reported from different forms of life. In this study, homology search based computational method was used to identify the conserved miRNAs in Gossypium hirsutum species from its EST sequences. We analyzed 337811 EST sequences of G. hirsutum against 8452 known plant miRNAs belonging to 73 plant species available in miRbase database using Blast program. Secondary structure prediction of the precursor sequences was done using MFOLD server. We identified 16 miRNAs from 15 families for which a phylogeny study was performed. Gene Ontology for the predicted miRNAs was done and the identified miRNAs where found to target transcripts having role in biosynthetic process, responses to chemicals, metabolic process regulation and many response related genes. These identified miRNAs can be used as biocontrol markers for plant’s defense and its yield under the schema of Integrated Pest Management strategies.

Phenol-formaldehyde (PF) resin was synthesized using bio-oil obtained by pyrolysis with and without alkali catalyst (potassium carbonate: K2CO3) (10 to 50 weight %). The pine sawdust was used as raw material of bio-oil. The chemical characterization of bio-oils was determined by GC-MS analysis. Oriented strandboard (OSB) panels were produced with the bio-based PF resins and then their technological properties were determined. As the amount of potassium carbonate catalyst increased up to 20 wt% in the PF resin, 24-h thickness swelling of OSB panels decreased from 15.4 to 14.3%, but further increment in the potassium carbonate catalyst content increased the thickness swelling (22.8%). The IB strength of the OSB specimens with PF resin with 10 wt% bio-oil produced with catalyst or pyrolysis process was found the same (2.18 N/mm2) and it was higher than the reference value (1.97 N/mm2). As the amount of bio-oil was increased to 20 wt%, the difference in the IB values between treated OSB and reference OSB was negligible. However, above the 20 wt% bio oil, it was observed a decrease trend in the IB values. The bending strength and bending modulus of the OSB specimens containing 20 wt% bio-oil were also found to be higher than those of the reference OSB specimens. It was concluded that the PF resin synthesized using bio-oil of (20 wt%) produced with and without alkali catalyst could be successfully used in the production of the OSB.

Adiponectin (APN), an adipokine secreted by adipocytes, is a well-known homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity through its anti-in?ammatory, anti-?brotic, and antioxidant effects. All these metabolic processes are mediated via two adiponectin receptors, AdipoR1 and AdipoR2. Many studies indicate that plasma adiponectin levels are decreased by obesity or cardiovascular diseases. In addition, adiponectin is one of the hormones with the highest plasma concentrations. The objective of this review is to analyze current knowledge concerning adiponectin and, in particular, its role in physiology and pathophysiology.