Natural compounds found in plants have been confirmed to play an important role in the treatment of many diseases. The medicinal plants have been demonstrated to act in various disorders by their anti-allergic, antitussive, antioxidant, anti-inflammatory, immuno-modulating activities, etc. Among the diverse array of the medicinal plants, Saffron (crocus sativus L.) has been reported to exhibit numerous pharmacological activities. Because it has bioactive pharmacological components; namely, safranal, picrocrocin, crocin and crocetin. Saffron constituents, especially crocin, have been indicated to have antioxidant, anti-inflammatory, anti-apoptosis and anti-tumor activities with chemo-preventive effects. Thus, the current study describes protective effects of saffron on the human body against some of disorders along with the probable mechanisms of action. The findings have shown that saffron can be used in some clinical settings for the prevention of cardio-pulmonary dysfunction, Diabetes Mellitus (DM) and stroke. It has the therapeutic application in varied types of diseases/syndromes including immune deficiency, neoplasia, metabolic syndromes, neurodegenerative or neuro-muscular disorders.

The increase in demand and introduction of stringent emission regulations resulted in the need to develop and implement innovative technologies towards improving the emission and performance characteristics of compression ignition engines. A hybrid metal matrix composite piston (HMMC) of Al7075 reinforced with 6% of 100 µm Silicon Carbide (SiC) and 4% of 100 µm Aluminium oxide (Al2O3) was fabricated. The HMMC piston was mounted on a compression ignition (CI) four stroke single-cylinder constant speed engine and the test was carried out with eddy current dynamometer attached with computerized data acquisition system. This paper is focused on the study of performance of Al7075-SiC-Alumina composite piston for compression ignition engine application. Experimental investigations were performed at injection pressure of 200 and 220 bar on both standard piston and HMMC piston and analysed the performance, combustion and emission behaviour of CI engine. From the results it was found that the HMMC piston exhibits an improved efficiency and thereby improving the lifetime of the engine. Though a little compromise in performance and emissions has been accepted, the implementation of HMMC pistons will reduce the carbon foot print of running an internal combustion engine.

: The coronavirus pandemic has compromised the quality of human life on the globe beyond boundary walls, distance barriers, and borders. Although comprehensive research and development are on the way, yet so for published literature contributes well to provide awareness, understanding, and somehow, treatment aspects of this infection. Hereafter, the working of health care providers has become challenging in their respective departments. The basic guidelines required to serve in a pandemic have been drafted which would further be matured with experiences. The purpose of the present study is to review and analyze the guidelines available for health care providers to identify, diagnose, manage, and treat the COVID-19 patients in their respective departments. To address the updates on clinical management of COVID-19, herein, a hypothesis has been devised. We recommend that all the clinical departments should coordinate and focus on the current guidelines so that we could fight against the pandemic successfully

Background: Pakistan\'s accounted for stillbirth rate is the most elevated in the world, with 43 cases for each 1,000 births, of which more than 3/4 happen in rural regions. The Global Women\'s and Children\'s Health Network keeps up the Maternal and Newborn Health Registry (MNHR) in fourteen research studies area of Punjab, Pakistan. In the previous ten years, the stillbirth pace of MNHR is high, and the pace of decay has been moderate. This exploratory examination means to comprehend the perspectives on women and normal birth chaperons on the continuous event of stillbirths in three districts (Rawalpindi, Bhakkar, and Dera Ghazi Khan) of Punjab, Pakistan.\nMethods: Researchers utilize an exploratory subjective examination plan, through Interviews (IDIs) and spotlight on rural female (FGDs = 10; n = 45) and normal birth orderlies (FGDs = 10; country female (FGDs = 10; n = 45) Group conversations (FGDs). n = 24) is a perpetual occupant of Dera Ghazi Khan. Furthermore, top to bottom meetings were led with female encountering stillbirths (IDI = 24). This examination presents the perspectives and encounters of female and TBAs in the Rawalpindi, Bhakkar, and Dera Ghazi Khan with respect to the higher frequency of stillbirths.\nResults: Because of worries about careful conveyance, helpless mentalities of talented medical care suppliers and low quality of care as a factor of administration conveyance, female are hesitant to get gifted/standard consideration when they need it. The significant expense of nursing care, the separation from the clinical organization, the burden of transportation, and the need to accompany relatives or towns to the clinical foundation are other significant variables that cause stillbirth without looking for clinical benefits. Accordingly, contrasted and talented medical care suppliers, untalented suppliers who incline toward the conventional type of birth chaperons are effectively accessible. Forthcoming relationships sharing their spouses or relatives limit them from seeing a specialist or counseling a specialist during pregnancy. As per the TBA after the baby is macerated, natural medication is given to the lady to get the contamination free from the lady\'s body and uterus. It is suggested that different female imagine as quickly as time permits to dispose of the disease.\nConclusion: women in this provincial local area have incredible worries about talented clinical mind and subsequently follow conventional traditions. A cognizant exertion is expected to raise female\' attention to dynamic wellbeing looking for practices during pregnancy, labor and the post pregnancy time frame. Simultaneously, particularly in general wellbeing establishments, the arrangement of deferential maternal consideration ought to be accentuated.

In this work, a new bone densitometry method is disclosed based on the photoacoustic response of chicken bones under the illumination of a continuous blue wave laser beam. Studies are performed on three chicken bone samples including keel, tibia, and humerus bones. A direct relation is found between the bone density and frequency of the generated photoacoustic sounds that can be used as a facile and reliable method to the bone densitometry and evaluating mineral content of the bones. The optical absorption, FWHM, amplitude, and peak of PA signals are studied for the bones and their dependencies to the bone mineral content are studied. Moreover, the main frequency and amplitude of the generated PA signals is directly dependent to the bone density. Also, keel bone with more pores shows a wider range of the amplified PA signals. We hope to extend the results of this study for humans by using simple X-ray photos and without needing any further pre-treatments on bones under the in vivo conditions.

This paper examines the effect of stern wedge length and height on the drag and trim of the chine-planing hull in calm water. To this end, the fluid flow is simulated by Star-CCM+ software applying overset mesh and k-ε turbulent model. Finite volume method is used for discretization of the fluid domain and volume of fluid is utilized for capturing the generated free surface. The considered model is a prismatic planing hull with deadrise angle of 24 degrees, mass of 86 kg, length (L) of 2.64 m and beam (B) of 0.55 m. For validation purpose, the numerical results of the drag and trim are compared against experimental data which displays good compliance. Subsequently, the hydrodynamic performance of the planing hull is investigated, and wedge effect is assessed. Stern wedge is located at the bottom and near the aft perpendicular of the hull to facilitate the moderate distribution. Various wedge lengths of 0.2B, 0.5B and B at two different heights of 5mm and 10mm are examined in order to find the hydrodynamic performance of the hull at various speeds. Trim angle, resistance, water surface elevation, porpoising, roster tail as well as stern and bow are computed and analyzed. Based on the numerical findings, it is concluded that when the wedge length increases, the drag and trim are decreased.