Background\n Sion\'s local paralysis (SLP) is the local application of neuromuscular blocking agents (NMBAs) to achieve local paralytic effects while avoiding the side effects of systemic paralysis.\n\nObjective:\nWe examined the changes in foreleg raising power after Sion\'s local paralysis (SLP) in an advanced porcine model.\n\nMethods:\nThis was a randomized, double blind, placebo-controlled, porcine study. Ten male Korean native Jeju black pigs were randomized into an intervention group (n = 5) and a control group (n = 5). The injection points were in the middle of the left trapezius muscle and middle of the left deltoid muscle, as described in a previous study. The control group received 2 ml normal saline (NS), with 1 ml injected at each point. The intervention group received 0.5 mg/kg succinylcholine diluted to 2 ml in NS, and 1 ml was injected at each point. The height of the left foreleg from the baseline (experimental table) was measured. We measured foreleg height and oxygen saturation at −4, −2, 0, +2, +4, +6, +8, +10, +20, +30, and +60 min. Unlike previous experiments, the study animals received pain stimuli before each measurement using the Kelly forcep that were clamped on their dew claws.\n\nResults:\nAfter SLP, foreleg height values immediately declined in the intervention group by approximately 20%. This effect was sustained for a few minutes. After satisfying the sphericity assumption (P-value = 0.015), repeated-measures analysis of variance (ANOVA) identified a significant main effect of group (P-value = 0.039) and time (P-value = 0.001) at 0, 2, 4, and 6 min. Hypoxic events were not observed.\n\nConclusions\nCompared with the control group, the foreleg raising power in the intervention group decreased significantly after SLP, without hypoxia, in an advanced pig model.
Introduction: The time of the COVID-19 pandemic can be emotionally challenging and stressful to all persons affected, and in particular those sub-groups of the population that are at an increased risk of mental health problems. Objectives: The main objective of the study is to analyse the gender differences on COVID-19 related stress and anxiety among students. Material and methods: This cross sectional study was conducted in Allama Iqbal Memorial Teaching Hospital, Sialkot during June 2020 to November 2020. The data was collected through non-probability consecutive sampling technique. The data was collected from students of final year and those who were doing house job. Results: The data was collected from 200 male and female participants. The mean age of the study patients was 24.4±10.6 years. Anxiety was much more common in men than in women (32.6% vs. 0, p<0.001). In response to a question about social distancing, \"Do you think it is necessary to avoid approaching people as much as possible until the COVID-19 situation is controlled?\" 157 people answered yes. Conclusion: It is concluded that stress significantly related to age, sex, employment status and education. It is apparent that the COVID-19 pandemic is having a substantial impact on post-secondary students\' academic experience, social relationships, and mental well-being.
Purpose of review: The COVID-19 pandemic comprises a significant worldwide wellbeing danger. Air travel worked with fast spread, albeit exacting travel boycotts and barricades eased back the spread. How does COVID-19 contrast from other arising viral infections in the previous 20 years? \nRecent findings: The episode of the infection is distinctive from various perspectives, for example, the people generally defenseless to the infection. Pregnant ladies of Zika and the older with COVID-19, their transmission vector, mortality and contagiousness are normally estimated by the fundamental proliferation number. Among arising irresistible sicknesses, there are huge contrasts in the danger of geographic spread through air travel. \nSummary: Compared with other arising viral sicknesses, for example, SARS and Ebola, COVID-19 has nothing to do with the most noteworthy case casualty rate, yet high conceptive rates, hyper-expansion occasions, and worldwide immunologically credulous populaces together lead to the world\'s most noteworthy case casualty Compared with some other pandemic, it has the most noteworthy extent of passing’s in the previous 20 years
Vietnam is the most vulnerable region to climate change and extreme climatic events, such as flash floods and droughts. This present research aims to explore the farm households’ beliefs, risk perception, climate change adaptation attitude and adaptation measures used by farmers in their farms to cope with climatic risks. Further, this study analyzed effect of climate change belief, awareness and adaptive attitudes on farmers’ adaptive behavior. A data set of 816 respondents was collected by using structured questionnaire from eight provinces in North mountains of Vietnam. By using ordinary least squares regression we analyzed farmers’ belief in climatic variations perception of climatic change, and risk attitude towards climatic hazards. Logistic regression was utilized to test binary decisions for specific adoption. Results revealed that farmers in the study area using most common climatic risk management strategies including applying new technologies, adjustment of the seasonal calendar, and diversification. Farmers were found to be most concerned about the risk in soil erosion and washout, followed by the stress of prolonging dry season and droughts. Risk perceptions and attitude toward climate change are essential factor in behaviors among farm households of northern mountains of Vietnam.
Objective: Study was designed to evaluate the expression status of HER2/neu receptor in breast cancer patients.\nTypes of study: Cross sectional study\nLocation and duration of study: This study was conducted in a duration of 10 months from March 2019 to December 2019 in department of Surgery, DHQ Hospital Faisalabad.\nBackground: Breast cancer is one of the most common in women worldwide and one of the most common cause of death in women. Occurrence of breast cancer varies in different parts of the world due to various factors. HER2 receptor is overexpressed in breast cancer patients.\nMaterial and Method: 150 patients were shortlisted for the study by applying various factors. Patients presented in the outdoor department of the surgery were aged between 22-60 years. Patients with ductal and lobular carcinoma were selected. Patients having the history of recurrence of disease and who rejected the histopathology were excluded from the study. Ethical committee approved the study and informed consent was taken from the patients or their attendees. Collected samples were sent to a reliable lab for HER2/Neu receptor status evaluation, tumor staging, progesterone, estrogen status and histopathological type. After that Hercep test was conducted and Minitab 16 version was used for statistical and data analysis.\nResult: Mean age of the total of 150 patients was 45.66 years. Ratio of positive and negative HER2/Neu receptors was observed to be 46 % and 54% respective in patients. Ratio of the patients with different grades of the cancer were found to be 24%, 39% and 37% for grade 1 tumor, grade 2 tumor and grade 3 tumor respectively. Out of the total patients 82% were found to have ductal carcinoma and 18% were diagnosed with lobular carcinoma. 78% of the patients were found to be positive against Estrogen receptor and 22% of the total patients tested negative against estrogen receptor. Progesterone receptors tested negative in 30% and positive in 70% of the total patients.\nConclusion: Overexpression of HER2/Neu receptor was observed and most of the patients had positive estrogen and progesterone. Grade-2 patients were found to be in highest number. HER2/Neu receptor showed no association with age group and obesity.
This article intends to zero in on the medical care issues brought by COVID-19 up with regards to Pakistan. At first, Pakistan needed \"standard working strategies,\" and the public authority needed to deliver test packs from China and Japan. Furthermore, the fast expansion in the quantity of cases has put a weight on the medical care framework because of infringement of lockouts and standard working techniques (SOP). This pestilence and its effect are getting greater and greater. Since antibody improvement has not been effective, \"crowd insusceptibility\" must be accomplished after around 3/4 of individuals are contaminated with the infection, which requires the penance of safe traded off residents for the public interest. Also, Pakistan\'s trying limit is restricted, so in any event, when the infection is spreading, most COVID-19 tests don\'t hold its imprint. The current circumstance has likewise raised worries about the public authority\'s capacity to react to the current clinical emergency. In such manner, medical services experts suggest that the public authority should make a capable move to guarantee better security for medical care experts. Distinguishing dubious cases, presenting individual defensive gear and taking regulatory measures to guarantee better wellbeing for medical services experts are crucial points in time for improving the anticipation of COVID-19 patients. Testing, following and bolting should be centered on the space where the bunch is identified. The best level of insurance should be given to clinical experts to make this pandemic reason genuine harm to death. A long haul underfunded medical services framework should be put resources into so Pakistan can fabricate the ability to battle the pandemic.
Objective: In the recent years, the ratio of pregnancy has increased at advanced maternal age \n(AMA) in comparison to the previous times where giving birth was common around age 18. The \npurpose of this revieq paper is to develop a comparative study of demographic and obstetric \nproperties of primiparous females at young and advanced maternal age.
Introduction: Hepatitis B is a risk factor for Health Care workers and medical students attending wards at hospital. Hepatitis B vaccine has been recommended since 1982 for use by health workers to prevent HBV infection. The aim of this study was to evaluate the vaccination coverage among HCWs and medical students, their level of knowledge regarding vaccination as well as and their beliefs regarding Hepatitis B vaccine.