The rising need for lithium batteries and growing environmental issues have prompted the develop3 ment of new sustainable recycling techniques. In this study, the new optimization framework, multi4 objective goal programming, enhances the efficiency and sustainability of lithium battery recycling pro5 cesses. The model represents a significant advancement in recycling techniques as it can simultane6 ously address multiple objectives such as cost reduction, environmental impact mitigation, workforce 7 optimization, and compliance with recycling regulations. An effectively simulated case study utilizing 8 random data highlights the effectiveness of the model by optimizing decision variables and attaining op9 timal objective function values. The study presents the efficiency of the proposed model by conducting 10 a thorough sensitivity analysis, which includes changing parameters and observing their impact on the 11 performance of the objective functions.

The Moringa oleifera also called “Drumstick tree”, to its various pharmacological uses and nutritional adaptability worth is comprehensively all over the earth. The tree parts; stem, bark, gum, roots, and mostly leaves are great provenance of vitamins, minerals, and numerous clinically beneficial secondary-metabolites and also a significant role in diabetic-resistance. The virtual-study may exist significant in terms of expanding the number of successful antidotes derived through this herb and plan to obtain the potent-phytochemicals amalgam of miracle tree even an agent for the curative potential opponent the Diabetes-Mellitus (DM) by computational screening. The structure of the top three selected phytochemicals was extracted from previous works of literature, Drug Bank database, PubChem-database, and screened with mutated protein from PDB structure (Crystal structure of insulin receptor kinase domain in complex with cis-(R)-7-(3-(azetidin-1-ylmethyl) cyclobutyl)-5-(3-((tetrahydro-2H-pyran-2-yl)methoxy)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine) through PyRx-docking tool. After, these three potent compounds: Anthraquinone, Serpentine, and Laurifolin were obtained, which showed successful binding within the targeted protein\'s active binding pocket; Anthraquinone-chain A: ASP-1177 aa (amino acid-complex) site, Laurifolin-Chain A: ASP-1110 aa, and Serpentine-Chain A: MET-1103 aa. The main features of the pharmacophore model based on ligands were revealed showed i.e. through molinspiration, swiss adme, admetSAR and exhibited acceptable drug-like properties; HBA (4,2,2), HBD (0,2,0), with the potent surface-binding active site: position A: 1159 by CASTp and structural visualized through Chimera Tool, and the protein functional network analysis of INSR Gene-associated with other via INSRR, IRS1, IRS2, SHC1, IGF1, PTPN1, INS, PTPN2, IGF1R, GRB14 of targeted plant Moringa oleifera against DM through STRING Database and gene-regulate expression were analyzed. Our finding proposes that docking potent these phytochemicals and gene functionality in M.oleifera may be utilized as a pharmaceutical candidate for diabetes and further investigate in future research.

The NRAMP (natural resistance-associated macrophage protein) family of transporter proteins has four members in Oryza sativa. OsNRAMP1, OsNRAMP2, OsNRAMP3, and OsNRAMP4 have been reported and considered for this study. These NRAMP transporter proteins have been studied in rice plants to transport a variety of metal ions such as Mn_2+, Cd_2+, Zn_2+, Fe_2+, and others. As a result, it\'s critical to predicting and properties of the OsNRAMP family of transporters computationally to study and understand them. In future research, it will be important to understand their biological insights. In this research, different in-silico methodologies, and strategies were used for the investigation of NRAMP-transporter proteins. The protein sequences\' physiochemical parameters were evaluated, putative transmembrane domains and helices, localization and hydrophobicity, phylogenetic analysis, correlated motif patterns of the transporter proteins were identified, and proteins-interaction associates were predicted. The online structure prediction method was used to obtain 3D models of all OsNRAMP transporter participants, which were then analysed. Since there is currently limited information about the functional and structural dimensions of these transporters, this research will anticipate the theoretical details regarding us.

The Natural killer (NK) cells\' ability to destroy cancerous cells is predominantly focused on the activation of the co-stimulatory and natural killer group two with receptor of member-D also called NKGD2/NKG2D. These identifies ligands that are MHC-Class1 structural homologs like that of the UL16 protein-binding type 2. The ULBP2 has been shown to mediate-natural resistance against the tumors mechanism in the condition of in-vitro, in-vivo, making it a possible target for producing the immune-therapeutic drugs for the diagnosis of the cancers and certain other viral diseases. In this present research, we created a stable and high-quality 3-D structure of the ULBP-2 protein through SWISS-Model also visualized by using UCSF-Chimera Tool. Moreover, the ULBP2 protein was prognosticated to be acts as antigenic, 11-discontinuous-B-Cell epitopes, 05 ULBP2 proteins antibody-based epitopes, and possible predicted the top hits of six linear B-cell epitopes. The ULBP2 protein carried seven cytotoxic-T lymphocytes (CTLs), two helper-T lymphocytes (HTLs), the LGKKLNVTTAWAQN is a promiscuous epitope MHC bounded to the T cells and with LRDIQLENY highest antigen scores in MHC molecule. Finally, the promising epitopes that could be successful in producing B-cell and T-cell mediated immunity against the required immune reaction to tumorigenesis were expected.

Recently, probiotics have been gaining high interest and are widely used in the commercial production of several kinds of food products. In this study, probiotic wafer production was accomplished with the addition of Lactobacillus rhamnosus LGG, Bacillus coagulans GBI-30, 6086 and Bifidobacterium animalis subsp. lactis BB-12. Fermented wafer leaf was used to improve the sensory characteristics and to ensure longer shelf-life. Samples were packed and stored in a climate chamber for 3 months. Shelf-life analyses of samples were made at 0, 15, 30, 60 and 90th day of storage. The chemical properties of wafer creams were determined. Results showed that L. rhamnosus LGG and B. coagulans GBI-30, 6086 count was higher than 7 log CFU/g although B. animalis subsp. lactis BB-12 count was below 6 log CFU/g. No statistically significant difference was found between the samples taken into sensory evaluation by trained panelists, and it was concluded that probiotic wafers are preferable for consumption. It was observed that there was no statistically significant difference in the chemical and microbiological analyses performed on the probiotic and non-probiotic wafers.

COVID-19 has become a global epidemic with more than 6 million active cases worldwide. This is a huge number even when the active cases have started to decrease in most of the developed world and the threat is looming of a second wave. The question is where the second wave would come from? Method: Our hypothesis is that the answer lies in the COVID-19 outliers. In most epidemiological and clinical studies, focus is on the patients who represent the majority population however, there is every likelihood that re-emergence of the virus will be the from the cases that are unique and not following the norm. Results and Conclusion: This may allow us to understand the behavior of SARS-CoV-2 better and allow us to hypothesize better about its biology. This paper analyzes 6 such COVID-19 patients reported by different regional Centers for Disease Control in China, which should be considered with regards to further spread and developing effective control of SARS-CoV2 epidemic.

The lean manufacturing system is widely used to reduce manufacturing waste in a variety of industries and to apply the same principles to institutions. The goal of this research is to teach aspiring engineers about lean tools. In the machine shop of an engineering college, various tools such as 5S, standard work, machine maintenance, and management concepts were implemented.

The current research aims to verify the effectiveness of training program based on artistic activities to improve some technical skills among a sample of children with intellectual disabilities who are able to learn. The study sample consists of ten children with intellectual disabilities who are able to learn (4 males - 6 females) whose age ranges from (6-8) years, with of age (6,700) years, a standard deviation is (0,8366), an average of intelligence Score (IQ) is (62.200). The researchers use the technical skills scale for educable children with intellectual disability (prepared by researchers), and a training program to improve technical skills skills among the sample of research (prepared by researchers). The program is applied in a a school of intellectual disabilities in Benha City in Qaliubiya Governorate. The results of the research indicate the effectiveness of training program in improving technical skills among educable children with intellectual disabily, where there are a significant statistical differences (0.05) between the mean ranks scores of the experimental group in pre and post assessment on technical skills scale, favoring the post assessment, and there are no significant statistical differences between the mean scores of the experimental group in post and follow-up assessment (after two months), on te chnical skills scale. \nKey words: Training Program – Technical Skills – Educable Children with Intellectual Disability.