BACKGOUND Randomized controlled trials (RCTs) have shown that dabigatran, rivaroxaban and warfarin cause similar bleeding rates. OBJECTIVE We performed a population-based study to determine the incidence of bleeding in patients with atrial fibrillation (AF) beginning dabigatran, rivaroxaban or warfarin. Consecutive patients initiating dabigatran, rivaroxaban, or warfarin for AF during a 3 year period were identified using a computerized database. Patients who bled and required hospitalization underwent chart review. Bleeding incidences were reported as rates per 100 patient-years of treatment. RESULTS 18249 patients were included: 9564 (52.4%) received warfarin, 5976 (32.7%) dabigatran, and 2709 (14.8%) rivaroxaban. Bleeding incidences were 3.9 (95% CI, 3.6-4.4) in warfarin-treated patients, 4.2 (95% CI, 3.7-4.7) in dabigatran patients, and 4.1 (95% CI, 3.0-5.3) in rivaroxaban patients. Intracranial hemorrhage (ICH) rates were 0.71 (95% CI, 0.56-0.90) in warfarin-treated patients, 0.4 (95% CI, 0.18-0.87) in dabigatran patients, and 0.27 (95%CI, 0.10-0.80) in rivaroxaban patients. GI hemorrhage rates were 1.88 (95%CI, 1.62-2.20) in warfarin-treated patients, 2.98 (95% CI, 2.4-3.5) in dabigatran patients and 2.39 (95%CI, 1.6-3.5) in rivaroxaban patients. CONCLUSIONS Consistent with RCTs, our study shows s
Constant Instantaneous Power control strategy for extracting reference currents for shunt active power\nfilters have been optimized using Fuzzy Logic control and Adaptive Tabu search Algorithm and their performances\nhave been compared. The acute analysis of Comparison of the compensation capability based on THD and speed\nwill be done, and recommendations will be given for the choice of technique to be used. The simulated results using\nMATLAB model are shown, and they will undoubtedly prove the importance of the proposed control technique of\naircraft shunt APF.
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