Cardiovascular Diseases (CVDs) represent a leading cause of disability and mortality including in developed countries. Hypertension, Atherosclerosis and stroke are prevalent causes of CVD onset, is mainly due to external stimuli, genetic factors and ethological risks. Among genetic risk, cyclooxygenase-2 (COX-2) has shown to be a key enzyme and an inducible isoform and involves in the production of diverse cytokine factors such as IL1B, IL6 and TNF alpha and other cascade enzymes over-expression during the inflammation of vital organs. However, COX-2 specifically played a significant role in the pathway and was obstructed by the potential inhibitor such as Tremuloidin, an effective therapeutic agent. Therefore, we hypothesize that Tremuloidin could be an efficient drug, ultimately controlling hypertension and CVD related risks and targeting in the regulation of a Cox-2 Enzyme. The main objective of this study is to find a suitable inhibitor for Cardiovascular Diseases. In the present investigation a molecular docking method was employed for determining and evaluating efficient and potential inhibitors of COX-2 enzymes, derived from plant based or natural source. Based on the binding affinities and diverse physiochemical characteristics, identified inhibitors were tested its nature for use as a drug. Moreover analyzing their suitability, absorption, distribution, metabolism and excretion (ADME) values were calculated by following Lipinkin\'s rule. Molecular docking scores and protein-Ligand complex stability were also assessed. This investigation outcome supports a remarkable insight on the interactive properties of plant based promising inhibitors of CVDs. Tremuloidin was screened against COX-2 based on the computational analysis the identified compounds Tremuloidin may have an effective anti-inflammatory activity and could potentially be developed as a therapeutic agent for CVD.

In this study, it was aimed to investigate the antibacterial activity of pomegranate peel’s extract and the cytotoxicity on the human dermal fibroblast primary cells to rationalize the safe usage of this extract. The antimicrobial efficiency of ethanol extract of pomegranate peels was evaluated against Acinetobacter baumannii, Burkholderia cepacia, Bacillus cereus, Citrobacter freundii, Cedecea neteri, Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus aureus MRSA ATCC 67101, Staphylococcus epidermidis and Streptococcus pneumoniae by disc diffusion and microdilution assays. At the same time, the effects of this extract on the human dermal fibroblast primary cells were determined by WST-8 assay. The ethanol extract of pomegranate peels was potentially effective with variable efficiency against A. baumannii, B. cepacia, B. cereus, C. freundii, C. neteri, E. faecalis, E. coli, P. aeruginosa, S. aureus MRSA ATCC 67101 and S. epidermidis at MIC\'s ranged from 100 to 500 μg/mL. However, it exhibits no inhibition activity against K. pneumoniae, S. aureus and S. pneumoniae. The ethanol extract of Punica granatum L. peel exhibited no cytotoxic activity against the normal human dermal fibroblast primary cells. According to results it may be suggested that this extract possess antimicrobial properties and the safety, and therefore, it can be used as a natural preservative ingredient in many industrial products.

Mulching is an approach towards weed suppression organically. A study in the field was carried out to check response of various mulching materials for weed control in wheat during 2014. Six mulch materials treatments were used along with Buctril super at the rate of 500 ml/acre. Study was designed as randomized complete block design with four repeats. The results exhibited significant decrease in weed density, relative weed density, fresh and dry plant biomass at 25, 50 and 75 days after sowing (DAS) where Buctril super at the rate of 500 ml/acre and mulch of black plastic were used followed by sugarcane bagasse and dry leaves of mulberry, as compared with control. Higher density of weed, relative weed density, fresh and dry plant biomass was observed in test species where lentil was applied with wheat and dry leaves of mulberry were incorporated. Net economic benefits in the form of benefit cost ratio (2.55) were higher where grass clippings were applied followed by sugarcane bagasse (2.43), mulberry leaves (2.49), while the low net economic benefits (1.72) were obtained when lentil with wheat was intercropped. It was concluded from the study that sugarcane bagasse and grass clippings can be a source to control weeds in the wheat field with minimum cost of production at Haripur, Pakistan and similar agro-climatic environment.

The variability of nitrogen (N) in soil restricts agricultural productivity. Hand-held Green seeker offers distinct advantage through field specific corrective N management strategies to increase the productivity and profitability of crops. A research study was conducted at National Agriculture Research Centre, Islamabad to examine the response of fodder oat to nitrogen management (N¬0 = control, N1 = 80 kg ha-1 basal dose, N2 = 40+40 kg ha-1 split doses, N3 = 40 kg ha¬-1 with one time managed with Green seeker and N4 = 20 kg ha-1 with two times managed with Green seeker) and seed rate (S1 = 80, S2 = 100, S3 = 120 and S4 = 140 kg ha-1). Data was recorded on agronomic, physiological aspects of the crop and economic analysis was performed for green seeker based N application against conventional recommended dose of nitrogen application. Significant differences were observed in crop performance using green seeker based nitrogen management and seed rate. Mean values showed that greater tillers plant-1 (6), fresh weight (16572 kg) and photosynthetic rate (11.64 mmol/m2/s) was noted in the treatment N4 (20 kg ha-1 and two time managed with Green seeker). Greater plant height (70.8 cm) and leaf area (64.14 cm2) were recorded in treatment N2 (40+40 kg ha-1 split doses) as compared to control. It was inferred from the results that oat yield was highly responsive to nitrogen management using Green seeker that enabled to apply proper dose under the field conditions. Based on results, it was recommended to apply initial dose of 20 kg ha-1 nitrogen along with two times managed with Green seeker for obtaining more green fodder yield and production in fodder oat.

The aim of this study is to determine the importance of liquidity, profitability, asset productivity, activity and solvency in cases of corporate financial distress. 105 firms in the extractive industry in the United States were analysed. The measure of corporate financial distress is the Altman Z score. The variables were measured in the last two years before the distressed firms declared bankruptcy. The results indicate that liquidity, profitability, asset productivity and solvency have an impact on the financial health of firms and therefore, on financial distress. The study further determines that activity ratio does not have a statistically significant relationship with financial distress.

Performance, emission and combustion studies were carried out on the ceramic coated diesel engine fueled with methyl ester of mango seed oil (MSBD) and MSBD blended with turpentine oil (MSBTO). The results of MSBD and MSBTO were compared with the results of diesel fuel (DF). The performance study showed that the MSBD and MSBTO showed 3.6% and 7.1% more BSFC value compared to that of DF in coated engine due to higher density and viscosity. The maximum brake thermal efficiency of 28% was observed for DF in coated engine compared to other fuels due to less fuel consumption of DF because of lower density. The emission characteristics displayed that the MSBTO fuel showed 12%, 15.1% and 29.1% reduction in the smoke density, NOx and CO respectively compared to that of DF in coated engine. However, the MSBD and MSBTO showed 17% and 21% more release of UBHC at full conditions compared to that of DF in coated engine due to low calorific values of MSBD and MSBTO compared to the calorific value of DF. Combustion study revealed that the MSBD and MSBTO displayed less cylinder pressure compared to that of DF in coated engine and the MSBTO fuel showed the 5.3% decrease in the cylinder pressure compared to that of DF in coated engine owing less heat liberation and lower cetane value.HRR followed the similar trend of variation of cylinder pressure and the MSBTO displayed 7.4% lower HRR compared to that of DF in coated engine.

It is very important to design systems for people with visual loss due to increasing accidents in recent years or people born blind to increase their integration into their social lives. For this reason, in this paper, it is aimed to design a robotic system and control approach that will enable blind people to move from one place to another. In this regard, it is desired that a mobile robot can go to a target point with the least error on a certain trajectory in a working environment known with its obstacles. In accordance with this purpose an analytical kinematic controller is designed, and it is proposed to determine control parameters via artificial neural network. The relationship between control gain values and mobile robot trajectory tracking errors are taught to two different artificial neural networks (MLP and RBNN), then numerous tests are performed to determine the gain values with the lowest error. The real-time tracking performances of the determined gain values are experimentally investigated and revealed for two different platform conditions (with and without obstacles) and two different target points.

Children have been participating in sports with the increasing numbers day by day. With the increasing rivalry, they are trying to find the ways to improve their performance to the best possible. As a result, the number of children who are adding resistance training to their training routines is also increasing. This raises myths about the harmful and risky nature of resistance training on children with many questions about its safety and effectiveness. Recent studies can remove doubts about the risk of injury, uselessness and ineffectiveness. With the proves from many studies for some decades, it is now accepted that properly controlled and supervised resistance training during childhood is not only safe and effective but also recommended by the world\'s leading healthcare and sports organizations for improving health and athletic performance. In the light of the scientific data, possible benefits, risks and application areas of resistance training for child athletes are discussed in this review.